Zinc deficiency in pregnancy Mimicking Acrodermatitis enteropathica: A Case Report

Abstract Background: Zinc is a vital micronutrient involved in numerous physiological processes, including immune function, epithelial integrity, and foetal development. During pregnancy, zinc deficiency can become pronounced due to increased maternal and foetal demands, sometimes mimicking inherited dermatological disorders such as acrodermatitis enteropathica (AE). Case Presentation: We report a rare case of a 21-year-old primigravida at 27 weeks’ gestation presenting with periorificial and acral dermatitis, alopecia, and persistent diarrhoea—clinical features classically seen in AE. Laboratory evaluation revealed significantly reduced serum zinc and alkaline phosphatase levels, with histopathology supporting a diagnosis of psoriasiform dermatitis. Imaging confirmed severe intrauterine growth restriction (IUGR). The patient responded rapidly to oral zinc supplementation and dietary modifications; however, due to worsening foetal Doppler findings, a caesarean section was performed at 32 weeks, delivering a growth-restricted but viable neonate. Conclusion: This case illustrates that acquired zinc deficiency during pregnancy can closely mimic AE, underscoring the importance of clinical awareness and timely intervention. Prompt diagnosis and supplementation not only resolve maternal symptoms but may also mitigate adverse foetal outcomes, such as IUGR and prematurity.