Impact of Age and Sex on Extra‐Brain, Off‐Target Binding in Tau PET Scans (18F‐FTP)
We observed that sex significantly affected extra-brain off-target signal in 18F-FTP PET imaging, while age has minimal effect, adding to previous evidence of off-target binding within brain regions. Further evaluation is necessary to understand the age-related effects on off-target regions. As a result, the variability introduced by sex may pose challenges to studying tau accumulation.
Authors
- Jeffrey L. Gunter (ORCID: https://orcid.org/0000-0001-7813-9078)
- Vamika Sharma
- Haakon R. Hol (ORCID: https://orcid.org/0000-0001-5625-8308)
- Seokbeen Lim (ORCID: https://orcid.org/0000-0002-4142-3478)
- Emily S. Lundt (ORCID: https://orcid.org/0000-0002-4754-8642)
- Sabrina M. Albertson
- VJ Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Marin Nycklemoe
- Mahathi Kandimalla
- David N Jacobson
- Daneil Kim
- Yurim Claire Choi
- Christopher G Schwarz
- Hoon‐Ki Min
- Tiffany Kung
- Sujala Ghatamaneni
- Clifford R. Jack
- Christopher Apgar
Institutions
- Sørlandet Hospital Arendal (NO)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107719
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00