Vascular plasticity and microglial mediators link blood‐brain barrier dysfunction to synaptic decline in cognitively typical aging independent of amyloid
These findings highlight a thromboinflammatory pathway underlying synaptic decline in typically aging older adults, driven by fibrinogen at the neurovascular interface. Targeting BBB integrity and its vascular-immune signaling may offer therapeutic opportunities to preserve cognition in aging, even in the absence of amyloid pathology.
Authors
- Katerina Akassoglou (ORCID: https://orcid.org/0000-0002-2632-1465)
- Nivetha Brathaban
- Hannah L. Radabaugh (ORCID: https://orcid.org/0000-0001-9820-9862)
- Nikolaos Karvelas (ORCID: https://orcid.org/0000-0003-1452-1192)
- Caleb H. Radtke
- Fanny Elahi
- Claudia Kunney
- Harrison W Chan
- Henrik Zetterberg
- Adam Ferguson
- Anna M Torten Rabinowitz
- Joel H Kramer
- Carlos Cruchaga
- Kaitlin B Casaletto
- Jonah Nadelmann Keller
Institutions
- Gladstone Institutes (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- University Memory and Aging Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Hope Center for Neurological Disorders (US)
- UK Dementia Research Institute (GB)
- Prevent Alzheimer’s Disease 2020 (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Global Brain Health Institute (US)
- University College London (GB)
- University of Gothenburg (SE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107288
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00