The Binding Patterns of Neurofibrillary Tangles Observed With High‐Resolution Autoradiography of <sup>18</sup> F MK 6240 and <sup>18</sup> F AV1451 Are Comparable and Predominantly Recognize Tangles at the Middle Stage
The emergence and validation of these new tau PET tracers have opened new opportunities for the development of more accurate diagnostic and management tools for AD. In our study on post-mortem sections, [<sup>18</sup>F]MK-6240 and [<sup>18</sup>F]Flortaucipir showed similar binding profiles with preference to middling tangle maturity levels.
Authors
- Tyler J. Bruinsma (ORCID: https://orcid.org/0000-0003-1880-689X)
- Ian Shin
- Christina M. Moloney (ORCID: https://orcid.org/0000-0002-4258-2294)
- Eleni Constantopoulos
- Ping Fang (ORCID: https://orcid.org/0000-0003-4379-3787)
- Sujala Ghatamaneni
- VJ Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Jonathan Graff Radford
- Ashley C. Wood
- Christopher G Schwarz
- David S. Knopman
- Courtney Hruska
- Hoon‐Ki Min
- Melissa E. Murray
- Jeyeon Lee
- Clifford R. Jack
- R. Ross Reichard
- David T. Jones
- Dennis W. Dickson
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Hanyang University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106581
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00