Lower CD8+ T‐cell Senescence Partially Mediates the Neuroprotection of Higher Aerobic Fitness
One pathway by which higher aerobic fitness is associated with lower Alzheimer's risk in older African Americans is through lower proportions of CD8+ T-cell senescence. The remaining 85% of the effect could include other immune, inflammatory, or other cellular phenotypes associated with age and physical function. These results highlight the immune and cognitive function benefits of a physically active lifestyle.
Authors
- Robert Perna
- Elizabeth Akbulut
- Alicia L Codrington
- Mark A. Gluck (ORCID: https://orcid.org/0000-0003-0538-2303)
- Mustafa Sheikh
- Darian A. Napoleon
- Wiktoria Piaszczynska
- Patricia Fitzgerald‐Bocarsly
- Stephanie Ghaly
- Andrew Gamil
- Imran Arshad
- Bernadette A. Fausto
Institutions
- Rutgers, The State University of New Jersey (US)
- Rutgers New Jersey Medical School (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107391
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00