Large‐scale cerebrospinal fluid proteomics identifies molecular signatures of disease progression across Alzheimer's disease and sporadic frontotemporal lobar degeneration
Findings highlight overlapping CSF proteomic alterations across AD and sporadic FTLD. Neuron-enriched protein communities robustly tracked with clinical severity across diseases, underscoring their potential as transdiagnostic biomarkers of disease progression and therapeutic targets for all aging brains.
Authors
- Joshua D. Downer (ORCID: https://orcid.org/0000-0003-3817-6733)
- Peter Alexander Ljubenkov (ORCID: https://orcid.org/0000-0002-3348-9215)
- Anne C. Sullivan (ORCID: https://orcid.org/0000-0001-9527-3607)
- Maria Luisa Gorno Tempini
- Rowan Saloner
- Bruce L. Miller
- Julio C. Rojas
- Kaitlin B Casaletto
- Lea T. Grinberg
- Lawren VandeVrede
- Howard J. Rosen
- Adam L. Boxer
- Julia D Webb
- Salvatore Spina
- Gil D. Rabinovici
- William W. Seeley
- Joel H Kramer
- Jennifer S. Yokoyama
- Renaud La Joie
Institutions
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107629
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00