Design, Synthesis and In vitro Assessment of di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5-tetraoxanes for Antiplasmodial and Anticancer Use

A library of novel non-symmetrical di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5- tetraoxanes has been prepared from complex-catalysed two-step one-pot direct oxidation approach and their in vitro antiplasmodial and cytotoxic potentials have been assessed against the chloroquine resistant FcB1 strain of Plasmodium falciparum, HeLa, A549 and A2780 cancer cells.

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Publication Details

Journal
OSF Preprints (OSF Preprints)
Published
2026-01-01
DOI
https://doi.org/10.17605/osf.io/9v3zs
Primary Topic
Metal-Catalyzed Oxygenation Mechanisms
Type
article
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article

Design, Synthesis and In vitro Assessment of di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5-tetraoxanes for Antiplasmodial and Anticancer Use

Marziyeh Raeispour
OSF Preprints (OSF Preprints)
Metal-Catalyzed Oxygenation Mechanisms
article

Design, Synthesis and In vitro Assessment of di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5-tetraoxanes for Antiplasmodial and Anticancer Use

Marziyeh Raeispour
article en

Abstract

A library of novel non-symmetrical di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5- tetraoxanes has been prepared from complex-catalysed two-step one-pot direct oxidation approach and their in vitro antiplasmodial and cytotoxic potentials have been assessed against the chloroquine resistant FcB1 strain of Plasmodium falciparum, HeLa, A549 and A2780 cancer cells.

OSF Preprints (OSF Preprints)
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Metal-Catalyzed Oxygenation Mechanisms
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Design, Synthesis and In vitro Assessment of di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5-tetraoxanes for Antiplasmodial and Anticancer Use — Marziyeh Raeispour · OSF Preprints (OSF Preprints) (2026) | TGRS Research Map | TGRS