Stability of Extracellular Vesicle Composition in Blood Specimens: Impact of Pre‐analytical Factors and Isolation Methods

Our findings demonstrate that EV composition remains stable in Protein Plus BCT compared to EDTA and ACD-A tubes, with a small number of exceptions. This insight into EV stability in blood specimens is crucial for advancing EV biomarker research in neurological disorders, including Alzheimer's disease, potentially enhancing diagnostic accuracy and therapeutic strategies.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_105924
Primary Topic
Extracellular vesicles in disease
Type
article
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article

Stability of Extracellular Vesicle Composition in Blood Specimens: Impact of Pre‐analytical Factors and Isolation Methods

Eunju Seong
Alzheimer s & Dementia
Extracellular vesicles in disease
article

Stability of Extracellular Vesicle Composition in Blood Specimens: Impact of Pre‐analytical Factors and Isolation Methods

Eunju Seong
article en

Abstract

Our findings demonstrate that EV composition remains stable in Protein Plus BCT compared to EDTA and ACD-A tubes, with a small number of exceptions. This insight into EV stability in blood specimens is crucial for advancing EV biomarker research in neurological disorders, including Alzheimer's disease, potentially enhancing diagnostic accuracy and therapeutic strategies.

Alzheimer s & DementiaVol. 21(S2)
Institut für Lacke und Farben (DE)
Reduced inequalities
Openalex Percentile: Top 34%
Extracellular vesicles in disease
DOIOpen Access PDFOpenAlex
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Stability of Extracellular Vesicle Composition in Blood Specimens: Impact of Pre‐analytical Factors and Isolation Methods — Eunju Seong · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS