Automated Thromboelastometry for Semiquantitative Assessment of High Heparin Concentrations: A Feasibility Study in Healthy Volunteers

This study on automated thromboelastometry demonstrated a dose-dependent prolongation of HEPTEM CT when heparin concentration increased from 0 to 6 IU/mL. Furthermore, ROC analysis on the ability of HEPTEM CT to detect heparin concentrations of ≥ 4 IU/mL indicated possible diagnostic potential. These novel findings suggest that HEPTEM CT is a feasible ROTEM Sigma parameter for semiquantitative assessment of heparin concentrations required for safe CPB. However, this remains to be verified in future clinical studies.