Rewiring the Lung–CNS Axis After Spinal Cord Injury

HaiRong Wu,1 Xiaolong Li,1 Wenjun Zhao,1 Yihan Li,1 Hang Zhang,1 Heng Yin,1,2 Xiaofeng Gu3 1Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine., Wuxi, 214071, People’s Republic of China; 2Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi, 210046, People’s Republic of China; 3Department of Orthopedics, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, 214023, People’s Republic of ChinaCorrespondence: Xiaofeng Gu, Email [email protected]: Spinal cord injury (SCI) is a catastrophic disorder of the central nervous system, most commonly resulting from traumatic events such as motor vehicle collisions or falls, but it can also arise from non-traumatic causes including neoplastic, infectious, or degenerative diseases. Respiratory complications are among the most frequent and life-threatening sequelae of SCI. In the acute phase, up to 80% of patients experience respiratory dysfunction, including pneumonia, atelectasis, and respiratory failure. These issues are particularly pronounced in individuals with high cervical injuries, where diaphragmatic and intercostal muscle paralysis impairs effective ventilation and clearance of secretions, substantially increasing the risk of infection. Emerging evidence underscores the bidirectional interplay between pulmonary pathology and central nervous system injury. SCI-induced autonomic dysfunction alters immune regulation, heightening susceptibility to pulmonary infections. Conversely, pulmonary complications can amplify systemic inflammatory responses, which may exacerbate neurological deterioration. Understanding the complex interactions between respiratory complications and SCI pathophysiology is essential for improving patient outcomes. This review therefore focuses on elucidating the mechanisms of pulmonary complications post-SCI and exploring therapeutic strategies to mitigate their impact on neurological recovery.Keywords: spinal cord injury, neuroimmune interaction, pulmonary microenvironment, lung–CNS axis