Aβ‐dependent trajectories of Braak stages for MK6240 and Flortaucipir tau PET
MK6240 follows a Braak stage-like pattern of abnormality as a function of Aβ burden, whereas for Flortaucipir, Braak IV is the first region to became abnormal. MK6240 becomes abnormal at lower Aβ burden levels compared to plasma p-tau217 and Flortaucipir but after plasma GFAP. Our findings suggest that MK6240 might detect tau pathology in earlier disease stages than Flortaucipir.
Authors
- DL Tudorascu
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- VJ Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Pamela C.L. Ferreira
- Livia Amaral
- Andreia Rocha
- David N. Soleimani‐Meigooni
- Thomas K Karikari
- Bruna Bellaver
- Brian A. Gordon
- Hwamee Oh
- Belen Pascual
- Guilherme Povala
- Pedro Rosa‐Neto
Institutions
- Houston Methodist (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Hospital de Sant Pau (ES)
- Mayo Clinic in Arizona (US)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107040
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00