Medial temporal lobe Tau‐Neurodegeneration <i>mismatch</i> from MRI and plasma biomarkers identifies vulnerable and resilient phenotypes with AD
T-N mismatch within MTL using MRI and plasma biomarkers revealed groups with varying vulnerability/resilience, with the vulnerable group displaying patterns of atrophy and cognition suggestive of LATE-NC. It offers a less invasive, cost-effective method for stratifying individuals for therapeutic interventions.
Authors
- Niyousha Sadeghpour (ORCID: https://orcid.org/0000-0001-8665-0335)
- Mengjin Dong
- Nidhi S. Mundada (ORCID: https://orcid.org/0000-0003-3108-6751)
- Long Xie
- Michael Tran Duong (ORCID: https://orcid.org/0000-0003-0312-5530)
- Yue Li (ORCID: https://orcid.org/0009-0005-8870-3898)
- Emily McGrew
- Laura E.M. Wisse
- Xueying Lyu
- Paul A. Yushkevich
- Christopher A Brown
- Sandhitsu R. Das
- David A. Wolk
Institutions
- Lund University (SE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107051
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00