CSF Proteome Analysis of <i>p</i> ‐Tau181 and Other Alzheimer's Disease Biomarkers Identifies Autotaxin–Lysophosphatidic Acid Signaling as Potential Therapeutic Targets
Unbiased profiling of circulating CSF proteins identified key proteins associated with β-amyloid and phosphorylated tau pathology. Biologically based diagnostic criteria may aid in the identification of unique pathogenic mechanisms.
Authors
- Martin Medrano (ORCID: https://orcid.org/0000-0003-3673-9088)
- Diones Rivera Mejía (ORCID: https://orcid.org/0000-0001-5935-8005)
- Alexander W. Rookyard
- Marielba Zerlin‐Esteves
- Lipi Das (ORCID: https://orcid.org/0000-0003-4428-7747)
- Caghan Kizil
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Honig Ls
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0009-0009-5731-1444)
- Rafael Lantigua (ORCID: https://orcid.org/0000-0003-4854-7331)
- Min N Qiao
- Prabesh Bhattari (ORCID: https://orcid.org/0000-0003-2991-5514)
- Elanur Yilmaz
- Lewis M Brown
- Badri N. Vardarajan
- Richard Mayeux
Institutions
- NewYork–Presbyterian Hospital (US)
- Pontificia Universidad Católica Madre y Maestra (DO)
- Columbia University Irving Medical Center (US)
- New York Hospital Queens (US)
- Instituto Tecnológico de Santo Domingo (DO)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107767
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00