Extracellular vesicles originating from induced pluripotent stem cell-derived chondrocytes facilitate the regeneration of osteoarthritic cartilage
This study highlights the therapeutic potential of iChondrocyte-sEVs, demonstrating their ability to promote both structural and functional regeneration of articular cartilage. These findings indicate a clinical conversion potential for OA treatment.
Authors
- Liyuan Jia
- Zhuojing Luo
- Pengzhen Cheng
- Xue Hao
- Meige Han
- Yaqian Hu
- Chuxin Zhou
- Weiguang Lu
- Guangyu Ding
- Liu Yang
- Jing Fan
Institutions
- Northwestern Polytechnical University (CN)
- Northwest University (CN)
- Xi'an Honghui Hospital (CN)
- China XD Group (China) (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.jot.2025.101035
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00