Genotype–phenotype interaction in Alzheimer's disease immune activation
High genetic risk relates to cerebrospinal fluid (CSF) immune markers amid evident neurodegeneration Immune polygenic risk scores (PRSs) capture genotype-phenotype associations in Alzheimer's disease (AD) immune activation AD PRSs and immune phenotype had an opposite relationship of the phenotype PRSs Importance of specific genetic predispositions in early AD immune phenotypes.
Authors
- Arne Nakling
- Ragnhild Eide Skogseth (ORCID: https://orcid.org/0000-0001-6688-9955)
- Berglind Gísladóttir (ORCID: https://orcid.org/0000-0002-1787-3006)
- Kaja Nordengen (ORCID: https://orcid.org/0000-0002-5897-6394)
- Ina S. Almdahl (ORCID: https://orcid.org/0000-0001-6070-4921)
- Lisa Flem Kalheim
- Gøril Rolfseng Grøntvedt (ORCID: https://orcid.org/0000-0003-2057-6683)
- Jonas Alexander Jarholm
- Stephanie Lindgård Knudtzon (ORCID: https://orcid.org/0009-0008-1628-5377)
- Francesco Bettella
- Bjørn‐Eivind Kirsebom
- Lene Pålhaugen
- Arvid Rongve
- Tormod Fladby
- Dag Aarsland
- Knut Waterloo
- Ole A. Andreassen
Institutions
- Oslo University Hospital (NO)
- University Hospital of North Norway (NO)
- King's College London (GB)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Stavanger University Hospital (NO)
- Akershus University Hospital (NO)
- Privatsykehuset Haugesund (NO)
- Deaconess Hospital (US)
- St Olav's University Hospital (NO)
- University of Bergen (NO)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/alz.70978
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- Norges Forskningsråd
- Helse Nord RHF
- Nasjonalforeningen for Folkehelsen
- Horizon 2020 Framework Programme