Metabolic signatures and predictive biomarkers of liposomal doxorubicin-induced hypersensitivity in breast cancer: A pilot study
Liposomal doxorubicin-induced hypersensitivity involves a metabolic network characterized by impaired anti-inflammatory responses (5,6-DHET/kynurenic acid depletion), histamine pathway activation (L-histidine accumulation), and aromatic amino acid dysregulation. These findings establish a novel biomarker framework for predicting hypersensitivity risk and provide mechanistic insights for targeted interventions.
Authors
- Yiyin Weng
- Lizhu Weng (ORCID: https://orcid.org/0000-0002-2211-3757)
- Wei Zhuang (ORCID: https://orcid.org/0000-0002-9845-2122)
- Xiaorong Su
- Wanlong Lin
- Yiqi Xiao
- Yanbin Zeng
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Northwest Women's and Children's Hospital (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
- Xiamen Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Cancer Treatment and Research Communications
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.ctarc.2026.101106
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00