Sirtuin1, 3 and 6 in serum of Alzheimer's Disease patients: An approach to establish as non‐invasive biomarkers

This study for the first time reports the concentration of SIRT1, SIRT3 and SIRT6 in serum of AD and MCI patients and reveals an inverse relationship of serum level of SIRT1, SIRT3 and SIRT6 with AD. The cut-off values with sensitivity and specificity shows the clinical relevance of SIRT3 and SIRT6 as serum protein markers for AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_106305
Primary Topic
Sirtuins and Resveratrol in Medicine
Type
article
Field-Weighted Citation Impact
0.00
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article

Sirtuin1, 3 and 6 in serum of Alzheimer's Disease patients: An approach to establish as non‐invasive biomarkers

Abhinay Kumar Singh, Sharmistha Dey
Alzheimer s & Dementia
Sirtuins and Resveratrol in Medicine
article

Sirtuin1, 3 and 6 in serum of Alzheimer's Disease patients: An approach to establish as non‐invasive biomarkers

Abhinay Kumar Singh, Sharmistha Dey
article en

Abstract

This study for the first time reports the concentration of SIRT1, SIRT3 and SIRT6 in serum of AD and MCI patients and reveals an inverse relationship of serum level of SIRT1, SIRT3 and SIRT6 with AD. The cut-off values with sensitivity and specificity shows the clinical relevance of SIRT3 and SIRT6 as serum protein markers for AD.

Alzheimer s & DementiaVol. 21(S2)
All India Institute of Medical Sciences (IN)
Openalex Percentile: Top 31%
Sirtuins and Resveratrol in Medicine
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Sirtuin1, 3 and 6 in serum of Alzheimer's Disease patients: An approach to establish as non‐invasive biomarkers — Abhinay Kumar Singh, Sharmistha Dey · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS