Prognostic utility of <i>p</i> ‐tau217 and tau PET in Alzheimer's disease
We found that p-tau217 positivity does not lead to a clear added prognostic value to tau PET in assessing risk of clinical progression in individuals with preclinical AD, particularly when measuring neocortical tau PET signal. These findings support imaging biomarkers as the primary prognostic tools for predicting cognitive impairment in early AD stages.
Authors
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Nesrine Rahmouni
- Wagner S. Brum (ORCID: https://orcid.org/0000-0002-9777-0559)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Andrei Bieger (ORCID: https://orcid.org/0000-0002-6669-2834)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Anderson Silva Corin (ORCID: https://orcid.org/0009-0004-1148-7085)
- Isabela Just de Jesus Vanni
- Pamela C.L. Ferreira
- João Pedro Ferrari‐Souza
- Arthur Macedo
- Eduardo R. Zimmer
- Joseph Therriault
- Lorenzo Fontura Brasil Barcellos
- Bruna Bellaver
- Marco Antônio Albini Valer
- Giovanna Carello‐Collar
- Diogo O. Souza
- Guilherme Povala
- Wyllians Vendramini Borelli
- Pedro Rosa‐Neto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Pelotas (BR)
- University of Pittsburgh (US)
- Hospital São Lucas da PUCRS (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107522
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00