First Intraventricular Chemotherapy for Relapsed Pediatric brain tumor in Iran a Case Report

<p>Abstract<br>Medulloblastoma is an aggressive pediatric brain tumor with a high risk of recurrence and metastasis despite current multimodal<br>treatments. Relapsed medulloblastoma is difficult to manage due to resistance to systemic chemotherapy and limited drug penetration<br>through the blood-brain barrier. This case report presents a 6-year-old patient with relapsed medulloblastoma treated with<br>intraventricular chemotherapy via an Ommaya reservoir in Iran. After failure of conventional chemotherapy, the patient received<br>Methotrexate, Cytarabine, and Thiotepa directly into the cerebrospinal fluid. This report highlights the feasibility and potential<br>benefits of intraventricular chemotherapy for relapsed medulloblastoma suggesting a valuable alternative therapeutic approach for<br>this challenging condition.</p>