Integrative Systems Approaches Identifying Mitochondrial Metabolic Disruptions in Alzheimer's Disease
Our findings integrate multiple data sources to provide a systems-level understanding of mitochondrial metabolism in AD. Sex-specific differences associated with mitochondrial dysfunction in AD were identified. We identify important mitochondrial transport proteins and metabolites that could potentially be used as druggable targets in AD.
Authors
- Robert J. Knight (ORCID: https://orcid.org/0000-0001-9927-6354)
- Eugenia Trushina (ORCID: https://orcid.org/0000-0002-6291-2860)
- Cory Funk
- H Gao
- Priyanka Baloni (ORCID: https://orcid.org/0000-0002-3382-4941)
- Jesse C. Wiley (ORCID: https://orcid.org/0000-0002-1430-772X)
- Alexandra Kueider‐Paisley
- Richa Batra
- Matthias Arnold
- Russell H Swerdlow
- Bin Zhang
Institutions
- Sage Bionetworks (US)
- University of Kansas (US)
- Duke University (US)
- University of Washington (US)
- Cornell University (US)
- Purdue University West Lafayette (US)
- Helmholtz Zentrum München (DE)
- Institute for Systems Biology (US)
- Yale University (US)
- Mayo Clinic in Arizona (US)
- Duke Medical Center (US)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Weill Cornell Medicine (US)
- Heinrich Heine University Düsseldorf (DE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106631
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00