Nanostructured Silver Selenide Based Electrode for Advanced Nonenzymatic Electrochemical Glucose Sensing Application

ABSTRACT In this study, we investigate the electrochemical detection of glucose (GL) molecules using silver selenide (Ag 2 Se) nanoparticles as electrode material, synthesized by the hydrothermal method. The X‐ray diffraction (XRD) analysis was performed to reveal the crystallinity, crystal structure, and crystallite size of the synthesized nanomaterial. The morphology of the Ag 2 Se material was identified as a nanoparticle‐like structure having a size from 30 to 70 nm, as determined by scanning electron microscopy (SEM). The electrochemical GL sensing characteristics of Ag 2 Se nanoparticles were revealed using a glassy carbon electrode (GCE) executing electrochemical measurements like cyclic voltammetry (CV) and chronoamperometry (CA) in a 0.1 M NaOH electrolytic solution. The Ag 2 Se nanoparticles responded with an undeviating current pattern in the range from 40 to 1200 µM with the increasing GL concentrations. The Ag 2 Se nanoparticles/GCE electrode material performed the GL sensing activity within a linear range of 40‐480 µM, demonstrating a sensitivity of 700.8 µAmM −1 cm − 2 , and a higher sensitivity of 1432.817 µAmM −1 cm − 2 in the linear range of 540–880 µM. Additionally, the nanoparticles produced a rapid response time of 6 s and a limit of detection (LOD) of 64.8 µM. Finally, the synthesized Ag 2 Se nanoparticles exhibited outstanding GL electrocatalytic performances like high sensitivity, selectivity, reproducibility, and stability even after 30 days. The Ag 2 Se nanoparticles demonstrate promising potential as a GL sensing material, making them suitable for mass production and industrial applications.