<scp>PGC</scp> ‐1α Transcriptionally Regulated by <scp>ChREBP</scp> Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti‐Inflammatory Response
ChREBP alleviates NP by enhancing microglial fatty acid oxidation and anti-inflammatory phenotype via PGC-1α transcriptional activation, revealing a novel metabolic-immune axis for potential NP therapy.
Authors
- Ziwei Hu
- Xinli Liu (ORCID: https://orcid.org/0009-0002-9427-2201)
- Jian Jin (ORCID: https://orcid.org/0009-0009-4300-884X)
- Yubai Zhao
- H Chen
- Kangling Wang
- Xuefei Zhang (ORCID: https://orcid.org/0000-0001-7096-9667)
- Youxin Yu (ORCID: https://orcid.org/0009-0008-0855-7512)
- Yun Zhao (ORCID: https://orcid.org/0009-0009-3804-5291)
- Hongwu Zhan (ORCID: https://orcid.org/0000-0003-1909-5540)
- Wen Wu
- Yi Lu
- Lijie Gao
- Jiahui Pang
- Hui Zeng
- Yu Shi
Institutions
- Sun Yat-sen University (CN)
- Guizhou University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Zhujiang Hospital (CN)
- Guangdong 999 Brain Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/cns.70744
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00