Correlation Between Functional Connectivity in the Default Mode Network (DMN) and Plasma Biomarker Concentrations in Patients with Mild Cognitive Impairment
Since network reorganization is a characteristic feature of MCI and AD, with regions exhibiting increased or decreased activity, the observed inverse relationship between Aβ42/Aβ40 and functional connectivity between the right hippocampus and right precuneus (indicating that an increase in Aβ42/Aβ40 is associated with decreased functional connectivity, and vice versa) supports the disease's underlying pathophysiology. This finding provides a potential avenue for research and diagnostic monitoring. Further studies are needed to explore the functional impact of these alterations and their relevance to disease progression.
Authors
- Marjorie Cristina Rocha da Silva
- Isadora Cristina Ribeiro (ORCID: https://orcid.org/0000-0002-2433-1096)
- Brenda Costa Gonçalves
- Ítalo Karmann Aventurato (ORCID: https://orcid.org/0000-0001-9314-1109)
- Liara Rizzi (ORCID: https://orcid.org/0000-0001-9823-8647)
- Gabriela Barbosa Rodrigues
- Fernanda Guarino De Felice
- Ananssa Silva
- Thaís Lopes Pinheiro
- Marcio Luiz Figueredo Balthazar
- Fernando Cendes
- Luis E. Santos
Institutions
- University of California, San Francisco (US)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Queen's University (CA)
- D’Or Institute for Research and Education (BR)
- Hospital de Clínicas da Unicamp (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107675
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00