Imaging‐based Biological Staging for Alzheimer's Disease Prognosis
The integration of Aβ and tau PET imaging provides critical prognostic information in early disease stages, with neocortical tau deposition performing as a robust predictor of clinical progression. These findings reinforce the utility of imaging biomarkers for AD staging and prognosis, highlighting that the topography of tau tangle accumulation is a key factor in enhancing risk stratification of individuals with preclinical AD.
Authors
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Nesrine Rahmouni
- Wagner S. Brum (ORCID: https://orcid.org/0000-0002-9777-0559)
- Andrei Bieger (ORCID: https://orcid.org/0000-0002-6669-2834)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Anderson Silva Corin (ORCID: https://orcid.org/0009-0004-1148-7085)
- Isabela Just de Jesus Vanni
- João Pedro Ferrari‐Souza
- Arthur Macedo
- Eduardo R. Zimmer
- Joseph Therriault
- Lorenzo Fontura Brasil Barcellos
- Marco Antônio Albini Valer
- Giovanna Carello‐Collar
- Firoza Z Lussier
- Marco De Bastiani
- Bruna Bellaver
- Diogo O. Souza
- Pamela C.L. Ferreira
- Guilherme Povala
- Wyllians Vendramini Borelli
- Pedro Rosa‐Neto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Pelotas (BR)
- University of Pittsburgh (US)
- Hospital São Lucas da PUCRS (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107452
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00