Local brain aging maps proximity to Alzheimer's‐related cognitive impairment
Our results challenge the assumption that T<sub>1</sub>-weighted MRIs cannot reveal temporal dynamics of neurodegeneration. The patterns revealed by local AG maps recapitulate known neurodegenerative patterns of AD observed using imaging techniques that require exposure to radiation (i.e., positron emission tomography). The ability to employ spatiotemporally sensitive biomarkers that are non-invasive and informative of proximity to CI conversion reduces barriers to early detection of Alzheimer's disease.
Authors
- O. Vega
- Phoebe Imms (ORCID: https://orcid.org/0000-0002-7205-4177)
- Andrei Irimia (ORCID: https://orcid.org/0000-0002-9254-9388)
- Nikhil N Chaudhari
Institutions
- University of Southern California (US)
- King's College - North Carolina (US)
- King's College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107525
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00