Six-Color Multiplex Digital PCR Assays for Comprehensive Screening and Identification of Multiple Driver Mutations Associated with Pancreatic Carcinogenesis
These 6-color dPCR assays offer scalable solutions for improved throughput detection of KRAS and GNAS mutations. Their compatibility with commercially available platforms and streamlined workflow support their integration into clinical practice. Further optimization can enhance cluster interpretation in high-plex settings and facilitate expansion toward broader genomic targets.
Authors
- Taito Itoh (ORCID: https://orcid.org/0000-0002-2518-3865)
- Chiho Maeda
- Hidemasa Kawabata (ORCID: https://orcid.org/0000-0003-3657-1991)
- Yuko Omori (ORCID: https://orcid.org/0009-0004-8285-5340)
- Takuya Yamamoto (ORCID: https://orcid.org/0000-0003-3753-1211)
- Tetsuhiro Okada
- Nobue Tamamura
- Kazuya Koyama (ORCID: https://orcid.org/0000-0001-6946-9462)
- Hiroki Tanaka (ORCID: https://orcid.org/0000-0003-0900-0261)
- Miyuki Mori
- Yu Ohtaki
- Yusuke ONO
- Kenji TAKAHASHI
- Yanpeng Sun
- Yusuke Mizukami
- Mayumi Suzuki
Institutions
- Asahikawa Medical University (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Sapporo Higashi Tokushukai Hospital (JP)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1093/clinchem/hvaf181
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87