Comprehensive spatial and immune profiling of metastatic mismatch repair–deficient colorectal cancer reveals response to immunotherapy
Collectively, these findings highlight the importance of spatial immune architecture and macrophage polarization in shaping ICI responses in dMMR CRC and underscore the need for spatial profiling to guide immunotherapy strategies in metastatic disease.
Authors
- Hari Kang
- YunJae Jung
- Won-Suk Lee
- Se-Hee Kim
- Ilkyu Park
Institutions
- Gachon University (KR)
- Gachon University Gil Medical Center (KR)
Publication Details
- Journal
- Immunotherapy Advances
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1093/immadv/ltag001
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00