NODDI reveals white matter microstructural changes in isolated REM sleep behavior disorder
Our study highlighted widespread and complex bidirectional white matter microstructural alterations in individuals with iRBD, demonstrating significant correlations with dexterity and motor performance even during the prodromal stage. These results suggest that extensive white matter abnormalities occur early in prodromal α-synucleinopathies and highlight the value of advanced diffusion imaging techniques in characterizing iRBD and its potential prediction of phenoconversion to overt neurodegenerative disorders.
Authors
- Lynn Marie Trotti (ORCID: https://orcid.org/0000-0003-2329-6847)
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Daniel E. Huddleston (ORCID: https://orcid.org/0000-0003-0503-3736)
- Jason Langley (ORCID: https://orcid.org/0000-0001-9412-1265)
- A Videnović
- Stuart J. McCarter (ORCID: https://orcid.org/0000-0001-8158-8835)
- Elijah Mak (ORCID: https://orcid.org/0000-0002-6437-8024)
- R. Postuma
- Miglis Mf
- Albert A. Davis (ORCID: https://orcid.org/0000-0003-2042-8445)
- Hernis de la Cruz
- Susan R. Criswell (ORCID: https://orcid.org/0000-0001-8467-371X)
- Amélie Pelletier (ORCID: https://orcid.org/0009-0001-5930-9796)
- Jonathan Elliot
- Angela J. Fought (ORCID: https://orcid.org/0000-0002-7486-8596)
- Erik K. St. Louis (ORCID: https://orcid.org/0000-0002-2833-8826)
- VJ Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Owen Ross
- Kaylena Ehgoetz Martens
- Brad F Boeve
- Ziv Gan‐Or
- Kevin Duff
- Yo‐El Ju
- Jessica Locke
- Leah K. Forsberg
- Julie A. Fields
- Lee Neilson
- Jennifer S McLeland
- Yuzheng Nie
- Kendall James Nichols
- Toji Miyagawa
- Alon Y Avidan
- Tanis J Ferman
- Michele Hu
- Paul T Kotzbauer
- Singer Wolfgang
- Emmanuel Mignot
- Donald Bliwise
- Christopher G Schwarz
- Chengjie Xiong
- Xiaoping Hu
- Miranda Lim
- Jean‐François Gagnon
- Meghan Campbell
- Kejal Kantarci
- Michael J Howell
- Robert I. Reid
- Clifford R. Jack
- Carlos H Schenck
- Prashanthi Vemuri
Institutions
- University of California, Riverside (US)
- Montreal Neurological Institute and Hospital (CA)
- University of Minnesota (US)
- Barrow Neurological Institute (US)
- Mayo Clinic (US)
- Emory University (US)
- University of Waterloo (CA)
- Université du Québec à Montréal (CA)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- University of Oregon (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- WinnMed (US)
- University of Oxford (GB)
- Massachusetts General Hospital (US)
- Mayo Clinic in Arizona (US)
- University of Washington Applied Physics Laboratory (US)
- Washington School of Psychiatry (US)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Mayo Clinic in Florida (US)
- McGill University (CA)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106325
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00