Three-Year Follow-Up of Nivolumab-AVD Versus Brentuximab Vedotin–AVD in Adolescents With Advanced-Stage Classic Hodgkin Lymphoma on S1826

We present a subset analysis on the adolescent cohort of the S1826 randomized phase three trial, comparing nivolumab, doxorubicin, vinblastine, dacarbazine (N-AVD) to brentuximab vedotin-AVD (BV-AVD) in newly diagnosed advanced-stage (AS, stages III and IV) classic Hodgkin lymphoma (cHL). Among 994 patients enrolled, 24% (n = 240) were age 12-17 years. The 3-year progression-free survival (PFS) was significantly higher in the N-AVD group (93% [95% CI, 87 to 96]) compared with the BV-AVD group (82% [95% CI, 73 to 88]; hazard ratio, 0.37 [95% CI, 0.17 to 0.80]). One N-AVD and two BV-AVD patients received protocol-specified residual site radiotherapy (RT). Rates of febrile neutropenia and sepsis were low in both groups. Severe immune-related adverse events were infrequent, although thyroid dysfunction was seen in 7% with N-AVD. Sensory neuropathy (grade ≥2) was more frequent with BV-AVD (14% <i>v</i> 7%) by clinician report. Although premature discontinuation of therapy was reported in 12 N-AVD patients and four BV-AVD patients, no PFS events were noted in the N-AVD group. Patient-reported outcomes indicated less toxicity with N-AVD. N-AVD demonstrated high 3-year PFS in adolescents with AS cHL, with minimal RT use. S1826 exemplifies the benefits of harmonized clinical trial protocols, resulting in timely access to novel agents for adolescents.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2026-01-09
DOI
https://doi.org/10.1200/jco-25-00203
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
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article

Three-Year Follow-Up of Nivolumab-AVD Versus Brentuximab Vedotin–AVD in Adolescents With Advanced-Stage Classic Hodgkin Lymphoma on S1826

FG Keller, Christopher J. Forlenza, Alex Francisco Herrera, Andrew Doan et al.
Journal of Clinical Oncology
Lymphoma Diagnosis and Treatment
article

Three-Year Follow-Up of Nivolumab-AVD Versus Brentuximab Vedotin–AVD in Adolescents With Advanced-Stage Classic Hodgkin Lymphoma on S1826

FG Keller, Christopher J. Forlenza, Alex Francisco Herrera, Andrew Doan, Jonathan W. Friedberg, Richard A. Drachtman, Richard F. Little, Angela Punnett, H. Li, Bradford S. Hoppe, Sarah C. Rutherford, SK Parsons, Adam J. Lamble, Malcolm A. Smith, Joo Y. Song, Kara M. Kelly, David Hodgson, Joseph M. Unger, Andrew M. Evens, Sharon M. Castellino, Sonali M. Smith, Michael LeBlanc
article en

Abstract

We present a subset analysis on the adolescent cohort of the S1826 randomized phase three trial, comparing nivolumab, doxorubicin, vinblastine, dacarbazine (N-AVD) to brentuximab vedotin-AVD (BV-AVD) in newly diagnosed advanced-stage (AS, stages III and IV) classic Hodgkin lymphoma (cHL). Among 994 patients enrolled, 24% (n = 240) were age 12-17 years. The 3-year progression-free survival (PFS) was significantly higher in the N-AVD group (93% [95% CI, 87 to 96]) compared with the BV-AVD group (82% [95% CI, 73 to 88]; hazard ratio, 0.37 [95% CI, 0.17 to 0.80]). One N-AVD and two BV-AVD patients received protocol-specified residual site radiotherapy (RT). Rates of febrile neutropenia and sepsis were low in both groups. Severe immune-related adverse events were infrequent, although thyroid dysfunction was seen in 7% with N-AVD. Sensory neuropathy (grade ≥2) was more frequent with BV-AVD (14% <i>v</i> 7%) by clinician report. Although premature discontinuation of therapy was reported in 12 N-AVD patients and four BV-AVD patients, no PFS events were noted in the N-AVD group. Patient-reported outcomes indicated less toxicity with N-AVD. N-AVD demonstrated high 3-year PFS in adolescents with AS cHL, with minimal RT use. S1826 exemplifies the benefits of harmonized clinical trial protocols, resulting in timely access to novel agents for adolescents.

Journal of Clinical OncologyVol. 44(6)
Rutgers, The State University of New Jersey (US), Tufts Medical Center (US), Roswell Park Comprehensive Cancer Center (US), Memorial Sloan Kettering Cancer Center (US), Children's Hospital of Los Angeles (US), Emory University (US), University of Toronto (CA), Cornell University (US), Hospital for Sick Children (CA), Princess Margaret Cancer Centre (CA), University of Chicago (US), Fred Hutch Cancer Center (US), Seattle Children's Hospital (US), City of Hope (US), Aflac (United States) (US), National Cancer Institute (US), Mayo Clinic in Florida (US), Children's Healthcare of Atlanta (US), Weill Cornell Medicine (US), University of Rochester (US)
Good health and well-being
Openalex Percentile: Top 92%
Lymphoma Diagnosis and Treatment
DOISourceOpenAlex
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