<i>APOE</i> ε4 Does not increase rate of amyloid accumulation or tau phosphorylation in adults with Down Syndrome
We did not observe increased amyloidosis or tau phosphorylation in APOEε4 carriers with DS. Future studies targeting individuals aged 45-50 are suggested to investigate the potential APOEε4 effect on tau phosphorylation observed in this narrow chronological window, which is close to the average expected age of symptom onset of 52.5 years for DS.
Authors
- Lott It
- Omar Abdelmoity (ORCID: https://orcid.org/0009-0003-8560-4339)
- Sharon J. Krinsky‐McHale (ORCID: https://orcid.org/0000-0002-7205-7319)
- Julie K. Wisch (ORCID: https://orcid.org/0000-0003-3624-2784)
- J Harp
- G. Coker
- J.B. Burns
- Laura Ibanez
- Joseph H. Lee
- Beau Ances
- Shahid Zaman
- Lauren Ptomey
- Christy L. Hom
- Frederick A Schmitt
- Sigan L Hartley
- Elizabeth Head
- Mark Mapstone
- Bradley T Christian
- H. Diana Rosas
Institutions
- University of Southern California (US)
- Autism Research Institute (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Kentucky (US)
- University of Kansas (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- New York State Office for People With Developmental Disabilities (US)
- Massachusetts General Hospital (US)
- Hope Center for Neurological Disorders (US)
- University of Kansas Medical Center (US)
- Prevent Alzheimer’s Disease 2020 (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107707
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00