Blood‐based biomarker for identifying post‐mortem confirmed Cerebral Amyloid Angiopathy

Blood-based biomarkers capable of identifying CAA could play an important role in improving treatment outcomes by highlighting ARIA risk prior to treatment initiation. We found that plasma proteins related to inflammation, blood brain barrier dysfunction and cytoskeletal stability were significantly changed in participants with confirmed CAA. Further work will be required to replicate these findings in an independent dataset.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_105227
Primary Topic
Intracerebral and Subarachnoid Hemorrhage Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Blood‐based biomarker for identifying post‐mortem confirmed Cerebral Amyloid Angiopathy

Marisa N. Denkinger, Alpana Singh, Kari Dieckhoff, James Liu et al.
Alzheimer s & Dementia
Intracerebral and Subarachnoid Hemorrhage Research
article

Blood‐based biomarker for identifying post‐mortem confirmed Cerebral Amyloid Angiopathy

Marisa N. Denkinger, Alpana Singh, Kari Dieckhoff, James Liu, Antoine Leuzy, Alirez Atri, Geidy E Serrano, Nicholas J. Ashton, Thomas G Beach, Eric M. Reiman
article en

Abstract

Blood-based biomarkers capable of identifying CAA could play an important role in improving treatment outcomes by highlighting ARIA risk prior to treatment initiation. We found that plasma proteins related to inflammation, blood brain barrier dysfunction and cytoskeletal stability were significantly changed in participants with confirmed CAA. Further work will be required to replicate these findings in an independent dataset.

Alzheimer s & DementiaVol. 21(S2)
Banner Sun Health Research Institute (US), Banner Alzheimer’s Institute
Good health and well-being
Openalex Percentile: Top 29%
Intracerebral and Subarachnoid Hemorrhage Research
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