Acute anti‐Aβ antibody exposure induces microglial changes and significantly alters chemokine signaling
Intracranially injected anti-amyloid beta (anti-Aβ) antibody promotes an immediate microglial response.3D6 exposure resulted in fewer homeostatic and motile microglia subtypes.Acute 3D6 enriches for chemokine/cytokine signaling pathways.
Authors
- Erica M. Weekman (ORCID: https://orcid.org/0000-0003-1252-6547)
- Kate E. Foley (ORCID: https://orcid.org/0000-0001-5110-238X)
- Donna M. Wilcock
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/trc2.70201
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- BrightFocus Foundation
- National Institute of Neurological Disorders and Stroke