Staphylococcus aureus periprosthetic joint infection and its pathogenesis in total hip and knee arthroplasty: a narrative review

Staphylococcus aureus is the most common pathogen in periprosthetic joint infections (PJIs), capable of biofilm formation and resistance mechanisms, complicating diagnosis and treatment. PJIs remain a leading cause of total joint arthroplasty failure and are associated with significant morbidity, mortality, and healthcare and economic burdens. Biofilm formation by S. aureus on prosthetic materials is central to PJI persistence and antibiotic resistance. Novel treatment strategies, including copper-coated implants, show promise as adjunct therapies but require further clinical validation.