Muscle involvement in women carrying pathogenic <i>DMD</i> gene variants: A 6.5-year follow-up study

The progression of muscle involvement in women carrying pathogenic <i>DMD</i> gene variants is generally slow. However, those with severe baseline abnormalities on MRI-often associated with a lower age of symptom onset-experience a more rapid progression of muscle fat fraction, suggesting that baseline MRI findings could help predict future disease progression in this population.

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Publication Details

Journal
Journal of Neuromuscular Diseases
Published
2026-01-09
DOI
https://doi.org/10.1177/22143602251408549
Primary Topic
Muscle Physiology and Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Muscle involvement in women carrying pathogenic DMD gene variants: A 6.5-year follow-up study

Tuva Åsatun Solheim, Nanna Scharff Poulsen, H. Joensen, Freja Fornander et al.
Journal of Neuromuscular Diseases
Muscle Physiology and Disorders
article

Muscle involvement in women carrying pathogenic DMD gene variants: A 6.5-year follow-up study

Tuva Åsatun Solheim, Nanna Scharff Poulsen, H. Joensen, Freja Fornander, Zhe Lyu, Morten Dunø, John Vissing
article en

Abstract

The progression of muscle involvement in women carrying pathogenic <i>DMD</i> gene variants is generally slow. However, those with severe baseline abnormalities on MRI-often associated with a lower age of symptom onset-experience a more rapid progression of muscle fat fraction, suggesting that baseline MRI findings could help predict future disease progression in this population.

Journal of Neuromuscular Diseases
University of Copenhagen (DK), Rigshospitalet (DK)
Openalex Percentile: Top 92%
Muscle Physiology and Disorders
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