Unraveling the significance of methyltransferase like-3 in the pathogenesis of gastrointestinal tumors: A review

In developing countries, gastrointestinal cancer remains a major public health concern due to its high incidence and mortality rates, posing a serious threat to human well-being. N6-methyladenosine, an internal modification found in common eukaryotic RNAs, plays a critical role in the initiation and development of gastrointestinal tumors. Among the key players in N6-methyladenosine formation is methyltransferase-like 3 (Mettl3). This article examines the prognostic implications of Mettl3 expression in gastrointestinal cancers, shedding light on its potential as a biomarker for disease progression and patient outcomes. Understanding the intricate role of Mettl3 in gastrointestinal tumor pathogenesis holds promise for the development of targeted therapies and personalized treatment strategies. Further investigation into the molecular mechanisms and clinical implications of Mettl3 in these cancers will pave the way for more effective interventions and improved patient care in the future.