Tau exacerbates the development of motor disturbances but has no effect on the development of irritability across the Braak stages – The HEAD Study
Our study suggests that tau contributes to the development of motor disturbances but has no effect on the development of irritability across the AD continuum. These findings provide additional rationale for the development of new therapeutics aiming to mitigate motor disturbances and irritability in AD patients.
Authors
- DL Tudorascu
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Hussein Zalzale
- LUCAS PORCELLO SCHILLING
- Francieli Rohden (ORCID: https://orcid.org/0000-0002-9232-7371)
- VJ Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Marina Scop Medeiros
- Pamela C.L. Ferreira
- Livia Amaral
- Carolina Soares
- João Pedro Ferrari‐Souza
- David N. Soleimani‐Meigooni
- Bruna Bellaver
- Brian A. Gordon
- Hwamee Oh
- Belen Pascual
- Guilherme Povala
- Eduardo R. Zimmer
- Pedro Rosa‐Neto
Institutions
- Houston Methodist (US)
- Universidade Federal do Rio Grande do Sul (BR)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Instituto do Cérebro (BR)
- University Memory and Aging Center (US)
- Mayo Clinic in Arizona (US)
- Hospital São Lucas da PUCRS (BR)
- Global Brain Health Institute (US)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105322
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00