Brain‐derived neurotrophic factor and cognitive function: Piloting dried blood spot sampling as a novel method in clinical trials for mild cognitive impairment
Feasibility of at-home DBSS collection was shown for older adult participants (including MCI) in a remote clinical trial and pilot analyses of DBSS cards returned in the mail yielded sufficient BDNF from punches for analyses. Furthermore, higher levels of BDNF correlated with better executive function thus providing preliminary validation of this novel approach. Results should be replicated in a larger sample.
Authors
- Vadim Yerokhin
- Paul Joseph Arciero (ORCID: https://orcid.org/0000-0001-7445-6164)
- Brian D. Cohen (ORCID: https://orcid.org/0000-0001-5815-2443)
- Gary C. Warner
- Valerie Needham
- Craig M. Story
- Cay Anderson‐Hanley (ORCID: https://orcid.org/0000-0001-7656-7511)
- Stella E. Panos (ORCID: https://orcid.org/0000-0002-3014-6014)
- Naomi Goldsmith
Institutions
- Union College (US)
- Skidmore College (US)
- UCLA Health (US)
- Gordon College (US)
- Pacific Heart Institute (US)
- Clifton Hospital (GB)
- University of Rochester (US)
- University of Tulsa (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106286
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00