Frequent at‐home multimodal measurements are more sensitive to progression than the gold‐standard clinic‐based ADAS‐Cog composite scale
Individual tablet-based tasks, completed autonomously at home by mild dementia patients, are more sensitive measurements of disease progression than ADAS-Cog. In on-going analysis we are quantifying the additional statistical power that multimodal/multivariate/composite measures may provide, and the resulting potential reductions in size, duration and risk of clinical trials in dementia.
Authors
- Brian Murphy (ORCID: https://orcid.org/0000-0001-7784-3434)
- Florentine Barbey (ORCID: https://orcid.org/0000-0003-1162-0195)
- Alison R. Buick (ORCID: https://orcid.org/0000-0002-0793-0695)
- James Rowe (ORCID: https://orcid.org/0000-0003-4710-4694)
- Shannon Diggin
- Hugh Nolan
- John Dyer
- Laura M Rueda‐Delgado
Institutions
- University of Cambridge (GB)
- Focus Ireland (IE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104932
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00