Clinical, microbiological, and genomic characterization of carbapenem-resistant Gram-negative bacteria in bloodstream infection: a multi-center study in Ecuador
Our findings demonstrate a high burden of CR-GNB, primarily due to K. pneumoniae and E. cloacae complex. Furthermore, the widespread distribution of blaKPC-2, blaNDM-1, and blaOXA-181 in high-risk clones, coupled with the frequent plasmid- and transposon-mediated mobilization of these genes, highlights the crucial role of horizontal gene transfer in the dissemination of resistance.
Authors
- Camilo Zurita-Salinas (ORCID: https://orcid.org/0000-0002-5553-4670)
- Gabriela Sevillano (ORCID: https://orcid.org/0000-0002-1133-5960)
- Andrés Herrera-Yela (ORCID: https://orcid.org/0000-0002-6351-3650)
- Juan José Romero (ORCID: https://orcid.org/0000-0001-7906-2463)
- Jeannete. Zurita
- María Belén Solís
- Cristina Moreno
Institutions
- Central University of Ecuador (EC)
- Pontificia Universidad Católica del Ecuador (EC)
- Zürcher Fachhochschule (CH)
- Hospital de Especialidades (MX)
- Hospital Vozandes (EC)
- Universidad Internacional SEK (EC)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1093/jambio/lxag008
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 21.79