Inhibition of TXNIP/NLRP3/GSDMD Pathway and Antioxidant Therapy Mitigate Cognitive Dysfunction Induced by Chronic Intermittent Hypoxia
These results reveal that microglial TXNIP/NLRP3/GSDMD pathway activation is a key mechanism linking CIH to neuronal injury in OSAS-related cognitive dysfunction. Inhibition of TXNIP/NLRP3/GSDMD pathway and antioxidant therapy could protect against CIH-induced cognitive dysfunction by ameliorating the damaging effects of cytokines of inflammation and oxidative stress from microglia, while preventing neuronal mitochondrial and cytomembrane injury and pyroptosis. This work identifies a promising target for pharmacological intervention in OSAS-related cognitive dysfunction. <i>Antioxid. Redox Signal.</i> 44, 373-392.
Authors
- X. Wang
- Lin Song (ORCID: https://orcid.org/0009-0007-9498-1805)
- Weiyu Zhang (ORCID: https://orcid.org/0000-0003-4330-5675)
- Xiwen Ou
- Song Liu
- Hongwei Wang
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Anhui Science and Technology University (CN)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1177/15230864251406615
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00