In vitro polarized macrophages ameliorate adverse cardiac remodeling in a mouse model of transverse aortic constriction
The main conclusion drawn from our results is that BMNC-Mφ improved or at least preserved LV function and architecture through metabolic recovery, immunosuppression, organized cell cycle/proliferation, and fibrosis modulation.
Authors
- Takura Taguchi (ORCID: https://orcid.org/0000-0002-9646-332X)
- Shunsuke Saito (ORCID: https://orcid.org/0000-0002-0829-2891)
- Kenji Miki (ORCID: https://orcid.org/0000-0001-7901-6133)
- T Kawamura (ORCID: https://orcid.org/0000-0003-2985-0036)
- Ulugbek R Yakhshimurodov
- Shigeru Miyagawa
- Kizuku Yamashita
- Imad Abugessaisa
Institutions
- Osaka Gakuin University (JP)
- Osaka University of Human Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.reth.2026.101061
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00