Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.
Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.
Authors
- Marina Padoan
- Clavel Jacqueline
- Melbye Mads
- Anthony Staines (ORCID: https://orcid.org/0000-0001-9161-1357)
- Joshua Arias (ORCID: https://orcid.org/0000-0001-6545-6656)
- Nicola J. Camp (ORCID: https://orcid.org/0000-0002-4788-1998)
- Vignesh Ravichandran (ORCID: https://orcid.org/0000-0002-1532-2593)
- Thierry Jo Molina (ORCID: https://orcid.org/0000-0002-3929-9754)
- Lucía Colodro Conde
- Elio Riboli
- Lucia Miligi
- Mark Liebow
- Qing Lan
- Roel C H Vermeulen
- Susan L Slager
- Paolo Boffetta
- Gilles Salles
- Joseph Vijai
- Bengt Glimelius
- Nicole Wong Doo
- Ruth C Travis
- Elisabete Weiderpass
- James R Cerhan
- Kenneth Offit
- Lesley F Tinker
- Mark P Purdue
- Hans-Olov Adami
- Alan A Arslan
- Angela R Brooks-Wilson
- Graham G Giles
- Kari E North
- Simonetta Bisanzi
- Karin E Smedby
- Alexandra Nieters
- Nikolaus Becker
- John J Spinelli
- Melissa C Southey
- Brian K Link
- Thomas M Habermann
- Immaculata De Vivo
- Henrik Hjalgrim
- James McKay
- Anne Lincoln
- Tongzhang Zheng
- Stephen J Chanock
- Marc Maynadie
- Mitchell J Machiela
- Demetrius Albanes
- Lindsay M Morton
- Eleanor Kane
- Zhaoming Wang
- Orestis A Panagiotou
- Lenka Foretova
- David G Cox
- Sonja I Berndt
- Paul Brennan
- Alpa V Patel
- Paige M Bracci
- Richard K Severson
- Wendy Cozen
- Sara Piro
- Nathaniel Rothman
- Amy Moore
- Stephanie Weinstein
- Roger L Milne
- Karen Curtin
- Hervé Ghesquières
- Alain Monnereau
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2026-01-09
- DOI
- https://doi.org/10.17615/tj1b-ra39
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00