Sera from patients with dermatomyositis and antisynthetase syndrome mediate muscle weakness, impair mitochondrial respiration and induce local cytokine production in muscle tissue
Serum from patients with IIM induced disease relevant phenotypes like those observed in muscle of patients, including weakness, local cytokine expression and mitochondrial dysfunction. These findings support the relevance of our model in recapitulating key features of IIM and further the mechanistic insights.
Authors
- Maryam Dastmalchi
- Cecilia Leijding (ORCID: https://orcid.org/0000-0003-4835-5997)
- Mattias Carlström (ORCID: https://orcid.org/0000-0001-9923-8729)
- Tomas A. Schiffer (ORCID: https://orcid.org/0000-0002-9077-2682)
- Begum Horuluoglu (ORCID: https://orcid.org/0000-0003-2241-5170)
- 義夫 田中 (ORCID: https://orcid.org/0000-0003-2294-0995)
- Daniel Andersson (ORCID: https://orcid.org/0000-0003-4548-702X)
- Suchada Kaewin (ORCID: https://orcid.org/0000-0003-1449-4219)
- Stefano Gastaldello (ORCID: https://orcid.org/0000-0001-7369-8452)
- Kristofer M. Andreasson
- Antonella Notarnicola
- Volker M. Lauschke
- Helene Alexanderson
- Angeles S. Galindo-Feria
- Ingrid E. Lundberg
Institutions
- Public Health Agency of Sweden (SE)
- Karolinska University Hospital (SE)
- Central South University (CN)
- Karolinska Institutet (SE)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.jaut.2025.103522
- Citations
- 1
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 31.52