Association of pesticide exposure with plasma Aβ‐42/40 Ratio: Translational evidence from 5xFAD mice and the Child Health and Development Studies
These findings show that DDE is an active metabolite of DDT and has lasting neurological effects on the amyloid system and cognition. This translational evidence highlights the role of early-life environmental exposures in AD risk and opportunities for early interventions to prevent disease progression.
Authors
- Isha Mhatre‐Winters (ORCID: https://orcid.org/0000-0003-3498-8355)
- Piera M. Cirillo (ORCID: https://orcid.org/0000-0003-4571-4544)
- Barbara A. Cohn (ORCID: https://orcid.org/0000-0002-9912-8447)
- Arturo Barahona (ORCID: https://orcid.org/0000-0001-5982-9516)
- Ferass M. Sammoura
- Nickilou Y. Krigbaum (ORCID: https://orcid.org/0000-0001-5034-7991)
- Pam Factor‐Litvak
- Yoonhee Han
- Dean P Jones
- Young‐Mi Go
- Bruce Link
- Jason R Richardson
Institutions
- University of California, Riverside (US)
- Emory University (US)
- University of Georgia (US)
- Florida International University (US)
- Public Health Institute (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106002
- Primary Topic
- Pesticide Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00