Population enrichment strategy using <i>APOE</i> ε4 genotype in tau‐targeting trials for preclinical Alzheimer's disease
Our findings suggest that combining APOEε4 status with Aβ positivity may be a cost-effective strategy for enriching participant selection in AD tau-targeting trials focusing on asymptomatic individuals, reducing required sample sizes and trial costs.
Authors
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Nesrine Rahmouni
- Wagner S. Brum (ORCID: https://orcid.org/0000-0002-9777-0559)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Laura Rosso (ORCID: https://orcid.org/0000-0002-0304-5840)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Andrei Bieger (ORCID: https://orcid.org/0000-0002-6669-2834)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Pamela C.L. Ferreira
- João Pedro Ferrari‐Souza
- Arthur Macedo
- Eduardo R. Zimmer
- Lucas Bastos Beltrami
- Joseph Therriault
- Bruna Bellaver
- Giovanna Carello‐Collar
- Diogo O. Souza
- Guilherme Povala
- Wyllians Vendramini Borelli
- Pedro Rosa‐Neto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- Hospital São Lucas da PUCRS (BR)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107489
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00