Beyond evidence hierarchies: Leveraging randomized controlled trials and real‐world data to advance the value of maternity care

While existing literature has compared the methodological strengths and limitations of randomized controlled trials (RCTs) and real-world data (RWD) in general medical research, two critical gaps remain unaddressed: (1) no prior communication papers have specifically examined this comparison in the context of maternity care where unique ethical and practical considerations exist, and (2) no studies have systematically compared cost-effectiveness analyses derived from RCTs versus RWD approaches-a crucial dimension for value-based maternity care decisions. This article examines how both approaches can strengthen the evidence base and support the delivery of value-based maternity care. We argue that neither RCTs nor RWD should be regarded as inherently superior in guiding decision-making. Each study design offers valuable insights, and their findings must be critically appraised in light of methodological rigor, context, and relevance, particularly when their results diverge.

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Publication Details

Journal
Acta Obstetricia Et Gynecologica Scandinavica
Published
2026-01-09
DOI
https://doi.org/10.1111/aogs.70094
Primary Topic
Maternal and Perinatal Health Interventions
Type
article
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article

Beyond evidence hierarchies: Leveraging randomized controlled trials and real‐world data to advance the value of maternity care

Yanan Hu, Joanne Enticott, Emily Joy Callander, Dr Valerie Slavin
Acta Obstetricia Et Gynecologica Scandinavica
Maternal and Perinatal Health Interventions
article

Beyond evidence hierarchies: Leveraging randomized controlled trials and real‐world data to advance the value of maternity care

Yanan Hu, Joanne Enticott, Emily Joy Callander, Dr Valerie Slavin
article en

Abstract

While existing literature has compared the methodological strengths and limitations of randomized controlled trials (RCTs) and real-world data (RWD) in general medical research, two critical gaps remain unaddressed: (1) no prior communication papers have specifically examined this comparison in the context of maternity care where unique ethical and practical considerations exist, and (2) no studies have systematically compared cost-effectiveness analyses derived from RCTs versus RWD approaches-a crucial dimension for value-based maternity care decisions. This article examines how both approaches can strengthen the evidence base and support the delivery of value-based maternity care. We argue that neither RCTs nor RWD should be regarded as inherently superior in guiding decision-making. Each study design offers valuable insights, and their findings must be critically appraised in light of methodological rigor, context, and relevance, particularly when their results diverge.

Acta Obstetricia Et Gynecologica ScandinavicaVol. 105(3)
University of Technology Sydney (AU), Griffith University (AU), The University of Queensland (AU), Gold Coast Hospital (AU), Monash University (AU)
Peace, Justice and strong institutions
Openalex Percentile: Top 93%
Maternal and Perinatal Health Interventions
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Beyond evidence hierarchies: Leveraging randomized controlled trials and real‐world data to advance the value of maternity care — Yanan Hu, Joanne Enticott, et al. · Acta Obstetricia Et Gynecologica Scandinavica (2026) | TGRS Research Map | TGRS