Impact of social determinants of health on ATN biomarkers and neurodegeneration in the ReDLat cohort

These findings highlight the significant impact of SDH on AT(N) biomarker profiles, underscoring social inequality's contribution to neurodegenerative risk. Lower SES, poorer nutrition, and limited education were strongly tied to unfavorable biomarker changes, emphasizing the need for targeted interventions addressing SDH disparities. Future longitudinal studies should clarify the mechanisms underlying these associations to better inform dementia prevention strategies. By addressing these modifiable SDH factors, public health initiatives may help reduce dementia risk across diverse populations worldwide. Additional research is warranted.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_106516
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Impact of social determinants of health on ATN biomarkers and neurodegeneration in the ReDLat cohort

Matías Pizarro, Hernando A Santamaría‐García, Felipe Cabral‐Miranda, Martín A. Bruno et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Impact of social determinants of health on ATN biomarkers and neurodegeneration in the ReDLat cohort

Matías Pizarro, Hernando A Santamaría‐García, Felipe Cabral‐Miranda, Martín A. Bruno, David Ramírez Aguillón, Ariel Caviedes, Carolina González, Andrea Z. Slachevsky, Hernan Hernandez, José Alberto Ávila Funes, Claudia Duran‐Aniotz, Nickole P. Marin‐Díaz, Diana L Matallana, Joaquín Migeot, María Isabel Behrens, Agustin Ibanez, Nilton Custodio
article en

Abstract

These findings highlight the significant impact of SDH on AT(N) biomarker profiles, underscoring social inequality's contribution to neurodegenerative risk. Lower SES, poorer nutrition, and limited education were strongly tied to unfavorable biomarker changes, emphasizing the need for targeted interventions addressing SDH disparities. Future longitudinal studies should clarify the mechanisms underlying these associations to better inform dementia prevention strategies. By addressing these modifiable SDH factors, public health initiatives may help reduce dementia risk across diverse populations worldwide. Additional research is warranted.

Alzheimer s & DementiaVol. 21(S2)
Universidade Federal do Rio de Janeiro (BR), Adolfo Ibáñez University (CL), Pontificia Universidad Javeriana (CO), Universidad de Antioquia (CO), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX), Hospital del Salvador (CL), Universidad Católica de Cuyo (AR), Forum Solidaridad Perú (PE), Hospital Clínico de la Universidad de Chile (CL), Institute of Peruvian Studies (PE), Hospital Universitario San Ignacio (CO), Global Brain Health Institute (US), Universidade Federal do Estado do Rio de Janeiro (BR)
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Openalex Percentile: Top 28%
Dementia and Cognitive Impairment Research
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