Association of prenatal glycemic marker cumulative exposure with placental DNA methylation change
Increased glycemic marker exposure was associated with placental DNA methylation near genes enriched for inflammatory and cardiometabolic pathways. Placenta-mediated epigenetic mechanisms may link maternal glycemic dysregulation and offspring's disease risk.
Authors
- Prabhavi Wijesiriwardhana
- Nigus Gebremedhin Asefa (ORCID: https://orcid.org/0000-0001-5680-5527)
- Richard J. Biedrzycki (ORCID: https://orcid.org/0000-0003-1994-2295)
- Fasil Tekola-Ayele
- Tesfa Dejenie Habtewold
Institutions
- National Institute on Aging (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1210/clinem/dgag006
- Citations
- 1
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 41.10