Associations between Plasma Metabolites, Dementia and Modifiable Risk Factors

Metabolomic signatures improved dementia prediction beyond established clinical risk factors and mediated the relationship between these risk factors and dementia. MRS were strongly associated with volume changes in multiple brain regions. This study implicates early metabolic pathobiology in the development of dementia and may inform potential intervention strategies. Future research will employ advanced MR methods to further characterise these complex relationships.