The Interaction of Sex and Neuroplasticity in the Pathogenesis of Alzheimer's Disease
In this cohort of community-dwelling older adults, we found higher baseline levels of GAP-43, indicating increased neuroplasticity, are related to cross-sectional increases in tau pathology, especially in women, and longitudinal decline in cognition, exclusively in women. Findings suggest that differential responses to neuroplasticity in aging could help explain long-recognized sex differences in tau pathology and cognitive decline.
Authors
- K. Blennow
- Panpan Zhang (ORCID: https://orcid.org/0000-0002-2124-2733)
- Amalia Jo Peterson (ORCID: https://orcid.org/0000-0002-7015-7957)
- Corey J. Bolton (ORCID: https://orcid.org/0000-0002-1715-5370)
- Dandan Liu (ORCID: https://orcid.org/0000-0002-4534-1082)
- Angela L. Jefferson
- Henrik Zetterberg
Institutions
- University of Wisconsin–Madison (US)
- Vanderbilt University (US)
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- Wisconsin Division of Public Health (US)
- University College London (GB)
- University of Gothenburg (SE)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106533
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00